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ASCO 2021丨一文速览血液肿瘤口头报告

作者:肿瘤瞭望   日期:2021/5/6 16:22:04  浏览量:7214

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编者按:2021年美国临床肿瘤学会(ASCO)年会-虚拟会议将于2021年6月4~8日举行,今年血液肿瘤领域有哪些重要报告?美国东部时间4月28日10:00 AM,2021 ASCO的摘要标题发布,在三个血液肿瘤口头报告专场,共有27项口头报告发布。让我们一睹为快!

血液肿瘤口头报告专场1


专场:Hematologic Malignancies—Leukemia, Myelodysplastic Syndromes, and Allotransplant

时间:6月5日2:30 AM - 5:30 AM CST

 

标题:OPTIC primary analysis: A dose-optimization study of 3 starting doses of ponatinib (PON)


OPTIC研究的初步分析:3种起始剂量ponatinib(PON)的剂量优化研究

摘要号:7000

作者:Jorge E. Cortes, et al.

标题:Combination of ponatinib and blinatumomab in Philadelphia chromosome-positive acute lymphoblastic leukemia: Early results from a phase II study


ponatinib联合blinatumomab治疗费城染色体阳性急性淋巴细胞白血病:II期研究的早期结果

摘要号:7001

作者:Nicholas J. Short, et al.

标题:Phase 2 results of the ZUMA-3 study evaluating KTE-X19, an anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, in adult patients (pts) with relapsed/refractory B-cell acute lymphoblastic leukemia (R/R B-ALL)


KTE-X19(CD19 CAR-T细胞疗法)用于成人复发/难治性B细胞急性淋巴细胞白血病(R/R B-ALL)疗效与安全性:ZUMA-3研究2期结果

摘要号:7002

作者:Bijal D. Shah, et al.

标题:The results of multicenter phase II, double-blind placebo-controlled trial of maintenance ixazomib after allogeneic hematopoietic cell transplantation (alloHCT) for high-risk multiple myeloma (MM) from the Blood and Marrow Transplant Clinical Trials Network (BMT CTN 1302)


异基因造血干细胞移植(alloHCT)的高危多发性骨髓瘤(MM)患者ixazomib维持治疗的疗效与安全性:来自BMT CTN 1302的多中心、II期、双盲、安慰剂对照研究

摘要号:7003

作者:Taiga Nishihori, et al.

标题:Letermovir prophylaxis and cytomegalovirus reactivation in adult allogeneic hematopoietic cell transplant recipients with graft versus host disease


伴有移植物抗宿主病的异基因造血干细胞移植成人受者中letermovir的预防作用以及巨细胞病毒的再激活

摘要号:7004

作者:Delaney Wolfe, et al.

标题:Prospective longitudinal evaluation of microbiome diversity in patients with hematological malignancy undergoing allogeneic hematopoietic stem cell transplantation (HSCT)


接受异基因造血干细胞移植(HSCT)的血液肿瘤患者微生物组多样性的前瞻性纵向评估

摘要号:7005

作者:Emily Walsh, et al.

标题:Effect of olutasidenib (FT-2102) on complete remissions in patients with relapsed/refractory (R/R) mIDH1 acute myeloid leukemia (AML): Results from a planned interim analysis of a phase 2 clinical trial


olutasidenib(FT-2102)对复发/难治性IDH1突变型急性髓系白血病完全缓解的影响:一项2期研究的中期分析结果

摘要号:7006

作者:Stéphane De Botton, et al.

标题:Efficacy and safety of aspacytarabine (BST-236) as a single-agent, first-line therapy for patients with acute myeloid leukemia unfit for standard chemotherapy


aspacytarabine(BST-236)单药一线治疗不适于标准化疗的急性髓系白血病的疗效和安全性

摘要号:7007

作者:Jessica K. Altman, et al.

标题:Phase 1 first-in-human study of irreversible FLT3 inhibitor FF-10101-01 in relapsed or refractory acute myeloid leukemia


FF-10101-01(新型不可逆的FLT3抑制剂)治疗复发或难治性急性髓系白血病的1期人体研究

摘要号:7008

作者:Mark J. Levis, et al.


血液肿瘤口头报告专场2


专场:Hematologic Malignancies—Lymphoma and Chronic Lymphocytic Leukemia

时间:6月7日11:30 PM - 2:30 AM CST




标题:First results of a head-to-head trial of acalabrutinib versus ibrutinib in previously treated chronic lymphocytic leukemia


acalabrutinib对比ibrutinib用于经治慢性淋巴细胞白血病的头对头研究初步结果

摘要号:7500

作者:John C. Byrd, et al.

标题:Fixed-duration (FD) first-line treatment (tx) with ibrutinib (I) plus venetoclax (V) for chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL): Primary analysis of the FD cohort of the phase 2 captivate study


固定时间(FD)ibrutinib + venetoclax一线治疗慢性淋巴细胞白血病/小淋巴细胞淋巴瘤患者的疗效与安全性:2期研究FD队列的初步分析结果

摘要号:7501

作者:Paolo Ghia, et al.

标题:First-in-human study of lisaftoclax (APG-2575), a novel BCL-2 inhibitor (BCL-2i), in patients (pts) with relapsed/refractory (R/R) CLL and other hematologic malignancies (HMs)


新型BCL-2抑制剂lisaftoclax(APG-2575)治疗复发/难治性CLL及其他血液肿瘤的首个人体研究

摘要号:7502

作者:Sikander Ailawadhi, et al.

标题:ECOG-ACRIN E1411 randomized phase 2 trial of bendamustine-rituximab (BR)-based induction followed by rituximab (R) ± lenalidomide (L) consolidation for Mantle cell lymphoma: Effect of adding bortezomib to front-line BR induction on PFS


套细胞淋巴瘤患者苯达莫司汀+利妥昔单抗(BR)一线诱导治疗后利妥昔单抗(R)±来那度胺(L)巩固治疗的2期随机研究:一线BR方案加入硼替佐米对PFS的影响

摘要号:7503

作者:Mitchell R. Smith, et al.

标题:Real-world (RW) treatment (tx) patterns and outcomes of 3,455 previously untreated mantle cell lymphoma (MCL) patients (pts) in U.S. routine clinical practice


美国常规临床实践中3455例先前未经治套细胞淋巴瘤患者的真实世界治疗模式及结局

摘要号:7504

作者:Peter Martin, et al.

标题:The combination of venetoclax, lenalidomide, and rituximab in patients with newly diagnosed mantle cell lymphoma induces high response rates and MRD undetectability


Venetoclax联合来那度胺与利妥昔单抗方案为新诊断套细胞淋巴瘤患者带来高缓解率及MRD阴性检测结果

摘要号:7505

作者:Tycel Phillips, et al.

标题:Myeloablative versus non-myeloablative consolidative chemotherapy for newly diagnosed primary central nervous system lymphoma: Results of CALGB 51101 (Alliance)


新诊断原发性中枢神经系统淋巴瘤清髓性对比非清髓性巩固化疗的疗效与安全性:CALGB 51101研究的结果

摘要号:7506

作者:Tracy Batchelor, et al.

标题:CALGB 50801 (Alliance): PET adapted therapy in bulky stage I/II classic Hodgkin lymphoma (cHL)


I/II期巨块型经典型霍奇金淋巴瘤PET适应性治疗的研究(CALGB 50801)

摘要号:7507

作者:Ann S. LaCasce, et al.

标题:Efficacy and safety of tisagenlecleucel (Tisa-cel) in adult patients (Pts) with relapsed/refractory follicular lymphoma (r/r FL): Primary analysis of the phase 2 Elara trial


Tisa-cel治疗复发/难治性滤泡性淋巴瘤成人患者的疗效和安全性:Elara 2期研究的初步分析

摘要号:7508

作者:Stephen J. Schuster, et al.


血液肿瘤口头报告专场3


专场:Hematologic Malignancies—Plasma Cell Dyscrasia

时间:6月8日8:00 PM - 11:00 PM CST




标题:Upfront autologous stem cell transplantation (ASCT) versus carfilzomib-cyclophosphamide-dexamethasone (KCd) consolidation with K maintenance in transplant-eligible, newly diagnosed (NDTE) multiple myeloma (MM)


新诊断且适合移植(NDTE)的多发性骨髓瘤患者先期自体干细胞移植(ASCT)对比carfilzomib-环磷酰胺-地塞米松(KCd)合并carfilzomib维持治疗的疗效与安全性

摘要号:8000

作者:Kwee Yong, et al.

标题:Depth of response and minimal residual disease status in ultra high-risk multiple myeloma and plasma cell leukemia treated with daratumumab, bortezomib, lenalidomide, cyclophosphamide and dexamethasone (Dara-CVRd): Results of the UK optimum/MUKnine trial


Daratumumab、硼替佐米,来那度胺、环磷酰胺和地塞米松(Dara-CVRd)方案治疗超高危多发性骨髓瘤和浆细胞白血病的缓解程度及最小残留病变情况:英国optimum/MUKnine研究的结果

摘要号:8001

作者:Martin F. Kaiser, et al.

标题:Carfilzomib-based induction/consolidation with or without autologous transplant (ASCT) followed by lenalidomide (R) or carfilzomib-lenalidomide (KR) maintenance: Efficacy in high-risk patients


Carfilzomib诱导/巩固治疗联合或不联合自体干细胞移植,序贯来那度胺或carfilzomib-来那度胺(KR)维持治疗对于高危患者的疗效

摘要号:8002

作者:Francesca Gay, et al.

标题:Subcutaneous daratumumab + bortezomib, cyclophosphamide, and dexamethasone (VCd) in patients with newly diagnosed light chain (AL) amyloidosis: Updated results from the phase 3 ANDROMEDA study


新诊断轻链(AL)型淀粉样变性患者皮下给予daratumumab+硼替佐米、环磷酰胺和地塞米松(VCd)的疗效与安全性:ANDROMEDA 3期研究的最新结果

摘要号:8003

作者:Efstathios Kastritis, et al.

标题:Daratumumab (DARA) maintenance or observation (OBS) after treatment with bortezomib, thalidomide and dexamethasone (VTd) with or without DARA and autologous stem cell transplant (ASCT) in patients (pts) with newly diagnosed multiple myeloma (NDMM): CASSIOPEIA Part 2


新诊断多发性骨髓瘤患者接受硼替佐米、沙利度胺和地塞米松(VTd)方案联合或不联合daratumumab及自体干细胞移植治疗后,daratumumab维持治疗或观察:CASSIOPEIA研究第2部分的结果分析

摘要号:8004

作者:Philippe Moreau, et al.

标题:Ciltacabtagene autoleucel, a B-cell maturation antigen (BCMA)-directed chimeric antigen receptor T-cell (CAR-T) therapy, in relapsed/refractory multiple myeloma (R/R MM): Updated results from CARTITUDE-1


Ciltacabtagene autoleucel(BCMA CAR-T细胞疗法)治疗复发性/难治性多发性骨髓瘤:CARTITUDE-1研究的结果更新

摘要号:8005

作者:Saad Z. Usmani, et al.

标题:Efficacy and safety of elranatamab (PF-06863135), a B-cell maturation antigen (BCMA)-CD3 bispecific antibody, in patients with relapsed or refractory multiple myeloma (MM)


BCMA-CD3双特异性抗体elranatamab(PF-06863135)治疗复发或难治性多发性骨髓瘤的疗效和安全性

摘要号:8006

作者:Nizar J. Bahlis, et al.

标题:Updated phase 1 results of teclistamab, a B-cell maturation antigen (BCMA) × CD3 bispecific antibody, in relapsed/refractory multiple myeloma (MM)


BCMA×CD3双特异性抗体teclistamab治疗复发/难治性多发性骨髓瘤的1期研究结果更新

摘要号:8007

作者:Amrita Y. Krishnan, et al.

标题:Updated results of a phase 1, first-in-human study of talquetamab, a G protein-coupled receptor family C group 5 member D (GPRC5D) × CD3 bispecific antibody, in relapsed/refractory multiple myeloma (MM)


GPRC5D×CD3双特异性抗体talquetamab治疗复发/难治性多发性骨髓瘤的1期人体研究更新结果

摘要号:8008

作者:Jesus G. Berdeja, et al.

版面编辑:洪山  责任编辑:李春明

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